Last edited by Jubar
Tuesday, May 5, 2020 | History

5 edition of Drug-Receptor Thermodynamics found in the catalog.

Drug-Receptor Thermodynamics

Introduction and Applications

by Robert B. Raffa

  • 368 Want to read
  • 12 Currently reading

Published by Wiley .
Written in English

    Subjects:
  • Thermodynamics,
  • Pharmacology,
  • Drug Interactions,
  • Physical Biochemistry,
  • Medical,
  • Science,
  • Receptors, Drug,
  • Pharmacy,
  • General,
  • Medical / Pharmacology,
  • Drug receptors,
  • physiology,
  • Life Sciences - Biochemistry,
  • Binding sites (Biochemistry)

  • The Physical Object
    FormatHardcover
    Number of Pages802
    ID Numbers
    Open LibraryOL9396216M
    ISBN 100471720429
    ISBN 109780471720423

    Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest Manufacturer: Wiley-VCH. 5)drug receptor complex formation is entropically unfavored (causes loss in conformational degrees of freedom for both ligand and protein, leading to chaos in system) 6) therefore, highly favorable enthalpic contacts (interactions) between the .

    E-BOOK DESCRIPTION. This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and. Drug-Receptor Interactions Drugs can have two fates at the receptor site: 1. Irreversible covalent bonding with the receptor active site Active-site-directed irreversible inhibition Anticancer agents such as the alkylating agentsFile Size: 1MB.

    Also, see: Perrot's A - Z Dictionary of Thermodynamics for more information, which states that "statistical thermodynamics" is sub-division of equilibrium thermodynamics; or you could by read a book on statistical thermodynamics, such as: Erwin, Schrodinger (). Statistical Thermodynamics. Dover Publications, Inc.. ISBN This updated edition of Netter's Illustrated Pharmacology allows you to take a distinct visual approach to understanding both the basic science and clinical applications of pharmacology. Designed to be compatible and used in conjunction with other pharmacology resources, this medical reference book offers a vivid, uniquely effective visual presentation of the .


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Drug-Receptor Thermodynamics by Robert B. Raffa Download PDF EPUB FB2

Drug-Receptor Thermodynamics is the first book to provide in depth coverage of principles and applications of thermodynamic drug-receptor interactions. The book starts from familiar points, making thermodynamics accessible to anyone interested in how drugs work.

The ideas presented cover general principles as well as laying the groundwork for Format: Hardcover. Drug-Receptor Thermodynamics is the first book to provide in Drug-Receptor Thermodynamics book coverage of principles and applications of thermodynamic drug-receptor interactions.

The book starts from familiar points, making thermodynamics accessible to anyone interested in how drugs work. The ideas presented cover general principles as well as laying the groundwork for new ways of examining Drug-Receptor Thermodynamics book. Drug-Receptor Thermodynamics is the first book to provide in depth coverage of principles and applications of thermodynamic drug-receptor interactions.

The book starts from familiar points, making thermodynamics accessible to anyone interested in Price: $ "Drug-Receptor Thermodynamics" covers the general principles of thermodynamics and its use and utility in pharmacology; provides a review of actual applications arranged according to receptor Read more.

Drug-Receptor Thermodynamics is the first book to provide in depth coverage of principles and applications of thermodynamic drug-receptor interactions. The book starts from familiar points, making thermodynamics accessible to anyone interested in how drugs work.

Drug-Receptor Thermodynamics by Robert B. Raffa,available at Book Depository with free delivery worldwide. Thermodynamics and Kinetics of Drug Binding. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules.

the book provides a balanced view from different leaders in the. Life Sciences, Vol. 44, pp. Pergamon Press Printed in the U.S.A. MINIREVIEW THERMODYNAMIC ANALYSIS OF THE DRUG-RECEPTOR INTERACTION Robert B.

Raffa* and Frank Porreca Department of Biological Research, Janssen Research Foundation, Spring House, PA and Department of Pharmacology, University of Arizona Health Sciences Cited by: Drug-Receptor Interaction: Pharmacology, Binding and Thermodynamics – A Review Article (PDF Available) in Journal of Surface Science and Technology 25() January w Reads.

Determination of drug-receptor binding constants (association, K A, or dissociation, K D =1/K A) by radiochemical specific binding assays has proved to be an invaluable tool for screening of potential active determination of K A (or K D) values makes it possible, however, to calculate the standard free energy ΔG°=−RT ln K A =RT ln K D (T= K) of the binding Cited by: Receptor binding thermodynamics is a powerful tool to gain deep insight, at the molecular level, of the events which occur during drug–receptor interactions.

Thermodynamics and Structural Basis of Insulin Receptor Interactions with Phosphotyrosine Binding Domains (A. Farooq & M. Zhou). Thermodynamics of the Visual-pigment System (E. Ito & H. Suzuki). Thermodynamics of Protein Modules Involved in Tyrosine Kinase Signaling Pathways (J.

Bradshaw, et al.). Receptor binding thermodynamics is a powerful tool to gain deep insight, at the molecular level, of the events that occur during drug-receptor interactions.

This chapter focuses on the determination of thermodynamic parameters based on the van’t Hoff analysis as a traditional method to discover the enthalpic and entropic contributions during Cited by: 1. T1 - Thermodynamic aspects of drug-receptor interactions. AU - Hitzemann, Robert. PY - / Y1 - / N2 - Determination of whether a specific ligand-receptor interaction at equilibrium is enthalpy- and/or entropy-stabilized can be achieved by thermodynamic analysis, writes Robert by: Thermodynamics and Kinetics of Drug Binding Pdf Divided into two parts on the thermodynamics and kinetics of both drug-receptor interaction, the text provides the philosophical and conceptual foundation for characterizing binding mechanisms for drugs and other bioactive molecules.

It was introduced by W.D.M. Paton at the end of ’s when occupation theory failed to justify different drug actions. The theory considered that occupation alone was of no importance to the action of agonists, instead it is the act of making a drug and receptor associate which donates a unit of stimulus to the cells.

Receptor binding thermodynamics is a powerful tool to gain deep insight, at the molecular level, of the events which occur during drug–receptor interactions.

This paper deals with the study of the A 3 adenosine receptors in the general scenario of all receptors studied so far from this point of : Pier Andrea Borea, Stefania Gessi, Stefania Merighi, Katia Varani. T1 - Thermodynamic analysis of the drug-receptor interaction.

AU - Raffa, Robert B. AU - Porreca, Frank. PY - Y1 - N2 - Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other by: Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive : $   A widely observed feature of protein−ligand binding thermodynamics is the seeming tug-of-war between enthalpy and entropy.

15−18 In general, protein−ligand complexes that exhibit more negative enthalpies of binding do so at the cost of more positive −TΔS terms and vice versa. This enthalpy−entropy compensation effect is clearly Cited by:. The history of thermodynamics is a fundamental strand in the history of physics, the history of chemistry, and the history of science in general.

Owing to the relevance of thermodynamics in much of science and technology, its history is finely woven with the developments of classical mechanics, quantum mechanics, magnetism, and chemical kinetics, to more distant applied .Moved Permanently.

The document has moved by:   Receptor binding thermodynamics is a powerful tool to gain deep insight, at the molecular level, of the events which occur during drug–receptor interactions.

This chapter deals with the use of van't Hoff analysis as a traditional method of thermodynamic studies to discover the enthalpic and entropic contributions of a drug to its receptor Cited by: 2.